TIROFIBAN HYDROCHLORIDE

Brand Name & Strength

Aggrastat ® 0.25 mg/ml (50 ml vial)

Reconstitution

Not required

Further Dilution

IV infusion

Dilute up to 250 ml of diluent (max concentration: 50 mcg/ml)

Diluent

NS, D5 Calculation Infusion rate for CrCl > 60 ml/min (ml/hr) = 0.15 mcg/kg/min x Body Weight (kg) x 60 min/hr 50 mcg/ml Infusion rate for CrCl < 60 ml/min (ml/hr) = 0.075 mcg/kg/min x Body Weight (kg) x 60 min/hr 50 mcg/ml

Administration & Infusion rate

Slow IV Administer over 5 min

IV infusion

Administer according to individualized CrCl in 12 – 24 hr

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

24 hr -

Remarks

To be administered in combination with heparin Should not be administered in the same IV line as diazepam Do not use plastic containers in series connection